The roles of protein ubiquitination in tumorigenesis and targeted drug discovery in lung cancer

The malignant lung cancer has a high morbidity rate and very poor 5-year survival rate. About 80% - 90% of protein degradation in human cells is occurred through the ubiquitination enzyme pathway. Ubiquitin ligase (E3) with specificity plays crucial role process target protein, which usually occurs at lysine residue substrate protein. Different forms have different effects on proteins. Multiple short chains residues modify proteins, are favorable signals for degradation. dynamic balance adapted to physiological needs between deubiquitination intracellular proteins beneficial health organism. Ubiquitination an impact many biological pathways, imbalances these pathways lead diseases including cancer. tumor suppressor factors or carcinogen often progression proteasome system (UPS) treasure house research development new drugs cancer, especially targeting E3s. oncogene precise may provide bright prospect drug cancer; Especially proteolytic targeted chimerism (PROTAC)-induced technology will offer strategy discovery